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High alcohol intake (350-420g/week in males, 280-350g/week in females) was identified as a particularly detrimental factor for cancer mortality in MetALD patients, significantly increasing the risk (HR 7.632, 95% CI 1.77232.869, p=0.006)

ALA acts as a cofactor for pyruvate dehydrogenase and -keto-glutarate dehydrogenase activity (Schmidt et al., 1994), and is also required for the oxidative decarboxylation of pyruvate to acetyl-CoA, a critical step bridging glycolysis and the citric acid cycle (Reed, 1998)

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis