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Lamantia V, Bissonnette S, Beaudry M, et al

For severe major depressive disorder [identified using a Patient Health Questionnaire (PHQ)-9 score 20], an integrated approach combining pharmacotherapy and psychotherapy is preferred

Under low-oxygen conditions, mitochondrial electron transport chain dysfunction and hypoxia-induced activation of oxidases [478] synergistically drive pathological ROS accumulation [479] that overwhelms cellular antioxidant defenses