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Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex

2313-C EXTRAHEPATIC/INTRAPANCREATIC CYTOKINE PRODUCTION PROMOTES HEPATOCARCINOGENESIS FROM NONALCOHOLIC STEATOHEPATITIS Seita Kataoka 1 , Atsushi Umemura 1 , Kanji Yamaguchi 1 , Yuya Seko 1 , Michihisa Moriguchi 1 , Toshihide Shima 2 , Takeshi Okanoue 3 and Yoshito Itoh 1 , (1)Kyoto Prefectural University of Medicine, (2)Saiseikai Suita Hospital, Suita, Osaka, Japan, (3)Saiseikai Suita Hospital Background: Nonalcoholic fatty liver disease (NAFLD), the leading etiology of chronic liver disease, is mainly caused by insulin resistance and can lead to hepatocellular carcinoma (HCC)