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K., Hsu, A

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While a clear advantage of zebrafish models over lower organisms for multi-system disease modeling is their discrete organs, genome and transcriptome sequencing have not yet been widely performed in zebrafish PMD models to inform individual organism or organ level expression changes that may highlight novel aspects of disease pathophysiology and treatment targets

Riluzole but not melatonin ameliorates acute motor neuron degeneration and moderately inhibits sod1-mediated excitotoxicity induced disrupted mitochondrial ca 2+ signaling in amyotrophic lateral sclerosis