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There are different types of variants they can be non-problem causing (benign), disease-causing (pathogenic) or of unknown significance

Prevalence rates in other populations vary considerably and are influenced by multiple factors, including advancing age, increased body mass index, smoking status [144], genetic enzyme dysfunction, impaired availability of metabolic cofactors, excessive methionine intake, comorbid diseases, and the use of certain medications [76]

Methods), and using enrichment analysis found substantial shifts in the relative proportion of these groups among dimorphic and saprophytic species

[DOI] [PubMed] [Google Scholar] [160].Vik SB, Capaldi RA