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85 TGF-1 induces angiogenesis primarily by enhancing VEGF secretion under hypoxia and upregulating signaling proteins such as Smad3/4 and HIF1, which further increase VEGF transcriptional activity through histone acetyltransferase (p300), emphasizing the role of chromatin remodeling

The Long-Term Timeline: 2 to 3 Months and Beyond The most lasting benefits are structural and take time, especially where the nervous system is concerned