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It allows continued monitoring of the benefit/risk balance of the medicinal product

[9] In summary, while NAD+ Injection is a broadly applicable metabolic therapy, it should not be used by anyone allergic to it, and it is generally avoided in pregnant women, cancer patients, or those with serious chronic diseases, absent compelling medical rationale

Pathological outcomes are more likely to emerge when adaptive mechanisms are overwhelmed by chronic stressors, persistent chronodisruption, or underlying disease processes

Gahl WA, Dalakas MC, Charnas L, Chen KT, Pezeshkpour GH, Kuwabara T, Davis SL, Chesney RW, Fink J, Hutchison HT (1988) Myopathy and cystine storage in muscles in a patient with nephropathic cystinosis