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In the two epilepsy models as mentioned above, the decrease of class I HDACs initiates the acetylation of histone H4 protein in rat hippocampal neurons and thereby activates the factors involved in epileptogenesis such as immediate early genes (IEGs) (e.g

10.1038/s41579-020-00468-6 Nat

Using a rich, gentle moisturizer is essential to keep the skin hydrated during treatment