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Description

Excessive sugar and refined carbohydrates that promote oxidative stress through various metabolic pathways

[DOI] [PubMed] [Google Scholar] 95.Liew Z, Bach CC, Asarnow RF, Ritz B, Olsen J

While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death