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2 The pathophysiology of Parkinsons disease Parkinsons disease, first described by James Parkinson in 1817, is a complex, age-related, progressive, and multisystem neurodegenerative condition associated with dopaminergic neuronal loss and formation of -synuclein (-Syn) protein aggregation in neurons of the substantia nigra (SN) (Morris et al., 2024)

Bibcode:2013MicEc..65..995P

Patients with sleep disruption during GLP-1 therapy may benefit from glycine documented effects on sleep quality

It has also been reported that the -glutamylcysteine synthetase is not the limiting step in plants under heavy metal stress conditions and overexpression of a bacterial glutathione synthetase gene alone in Indian mustard results in higher concentrations of glutathione in the transgenic plant 31