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The iron chelator DFO has been shown to decrease ROS production, mitigate hemoglobin-induced neurotoxicity, reduce brain edema, and enhance functional outcomes in both in vivo and in vitro models of CH ( 3.6 Traumatic brain injury Traumatic Brain Injury (TBI) is followed by a cascade of secondary injuries, including the release of excitatory neurotransmitters and Fe 2+ , OS, LP, and the accumulation of ROS, all of which induce ferroptosis ( Additionally, miR-212-5p regulates prostaglandin-endoperoxide synthase-2 to reduce ferroptosis-induced neuronal death ( 3.7 Spinal cord injuries Spinal cord injuries (SCI), known for causing severe disability and mortality, present significant medical challenges worldwide

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