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Glutathione peroxidase 3 (GPX3) suppresses the growth of melanoma cells through reactive oxygen species (ROS)-dependent stabilization of hypoxia-inducible factor 1- and 2-

The study shows that female patients with melanoma had significantly better responses to BRAFMEK-targeted therapy than male patients, and in preclinical melanoma models, elevated AR expression impaired treatment efficacy, while AR inhibition improved responses

Eur J Neurol 17:14631470