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DHODH and mitochondrial GPX4 complement each other [86], suggesting that DHODH inhibitors could be potential treatments for GPX4-deficient cancers [87]

Maini RekdalVBessENBisanzJETurnbaughPJBalskusEP

1 Introduction Stroke, which contributes to a growing portion of the global medical burden, can be broadly classified into ischemic stroke and hemorrhagic stroke, with the latter incorporating intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) ( Ferroptosis, a type of programmed cell death associated with stroke, was initially identified in 2012 and displays distinctive features, such as changes in the structure and density of mitochondria (Figure 1 shows a flowchart summarizing natural products that target ferroptosis after strokes

K.MhlbauerM.StarrA