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The mechanism of decreased lipid turnover with aging may be due to decreased sympathetic tone (236)

It remains mainly at the animal experimental stage, lacking clinical trial data in humans

Full-length growth hormone produces fat loss but also elevates IGF-1 (with implications for cell proliferation and aging), worsens insulin sensitivity and elevates blood glucose (problematic for diabetics and pre-diabetics), promotes muscle growth and protein synthesis (which may be desired or unwanted depending on goals), causes fluid retention and edema in many users, and requires careful medical monitoring with regular blood work