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For example, an analysis of NHANES (99-02) data revealed that individuals with the highest serum levels of the six persistent organic pollutants (POPs) measured had a dose-dependent increase in risk for diabetes, up to an astonishing 38-fold increase

Nature Reviews Drug Discovery, 6(10), 821833.

This is one reason head-to-head binding assays dont always match head-to-head secretion experiments and why researchers occasionally get surprised when GHRP-6 outperforms GHRP-2 in certain model contexts despite lower receptor binding affinity on paper