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In the Krebs cycle, adenosylcobalamin can induce the accumulation of succinate, an antagonist of histone and DNA demethylation reactions catalyzed by enzymes of the 2-oxoglutarate-dependent dioxygenase family, which may favor the activation or inhibition of gene expression ( Figure 5 )

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A substance or method will be considered for inclusion on the WADA Prohibited List by the WADA List Expert Advisory Group if the substance or method meets two of the following three criteria: It has the potential to enhance or enhances sport performance