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It affects various bodily functions, including: Sperm production Sex drive Muscle strength and size Deepening of the voice during puberty Bone growth and strength Growth of facial, body, and pubic hair during puberty Development of the penis and testes Testosterone may play a role in hair loss later in life

Common areas of laboratory investigation include

Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic

Still, the risk, while diminished during winter, is not eliminated