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, 26 , 509-522.e6 (2017)

The only human trial ever registered (NCT02637284) was cancelled in 2016 without publishing results

PubChem Pathway Summary for Pathway SMP0087221, Glucose-Alanine Cycle, Source: PathBank

Other PTMs, such as methylation, are more context dependent, with the resultant chromatin state being determined by the specific amino acids in the histones that are modified, and the combination of PTMs on neighboring histones