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Quercetin and other polyphenols inhibit NLRP3 inflammasome assembly, thereby reducing caspase-1 activation and limiting the release of (IL-1, IL-18), this results in a significant reduction in neuroinflammatory cytotoxicity (Xue et al., 2017)

Casacuberta-Serra S, Gonzalez-Larreategui I, Capitan-Leo D, Soucek L

Phase II Trial of TAS-102 in Colorectal Cancer Patients With Circulating Tumor DNA-Defined Minimal Residual Disease After Adjuvant Therapy

When taken orally as a supplement, glutathione works from within to address the underlying causes of skin discoloration, offering a natural alternative to topical treatments