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Conclusion For patients with stable (chronic) coronary disease, the evidence reviewed here supports a clear sequencing principle: an adequate trial of guideline-directed medical therapy and intensive lifestyle modification should generally precede elective invasive revascularization in appropriately selected stable patients without high-risk anatomy

(August 2003)

Specifically, both the proportion of the aberrant IL7R low naive CD4 T cells and the associated core 20 gene signatures, including S100A4 , FOS , ORC4 , BCL11B , and PAG1 , were restored to levels observed in healthy controls

For those patients in the acute phase, pharmacotherapy provides the potential to improve function, reduce deformity, and stabilize scar progression (5)