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Liposomes have been used as drug carriers in therapeutic studies for malaria, cancer, breast cancer, and other diseases due to their targeting, controlled release, decreased drug toxicity, and enhanced drug stability (Memvanga and Nkanga, 2021

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Similarly, in MDD patients treated with SSRIs, 8-week treatment increased the KYNA/3-HK ratio and showed early increases in KYN/TRP at week 4 among responders [194]

The prodrug strategies investigated thus far have aimed to mask negative charges by incorporating enzymatically cleavable hydrophobic chemical moieties that facilitate intracellular permeation