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12 Assess reflexes, strength, sensation On physical examination, particular attention should be focused on searching for abnormalities indicating large nerve fiber involvement (eg, absent deep tendon reflexes, weakness of the toes)

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The significant demyelination in the CC and PFC may play essential roles in developing depressive-like behaviors, and the beneficial effects of ALC in accelerating the remyelination process may be attributed to providing the necessary energy in this demyelinated mouse model of MS