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Quercetin, GSH, vitamin C, vitamin B9, carotenoids, carnitines, polydatin, and taurine have also been reported to protect the testis from damage and improve semen quality, but their roles in ferroptosis have not been elucidated [127,128,129,130]

While severe OXPHOS impairment can impose bioenergetic limitations and reduce tumor fitness, particularly under in vivo selection pressures, partial respiratory defects may instead confer a selective advantage by enhancing metabolic plasticity and stress tolerance [219, 220]

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