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Description

The copper concentration used in experiments critically influences cellular responses: low levels (0.10.1.2mmol/l) induce physiological/adaptive transcriptional changes, while higher levels (0.4-0.4.6mmol/l) trigger toxic, stress-related responses [24]

Thus, the coordinated expression of Dnmts , key to the dynamic methylation and demethylation pattern, plays an important role in regulating neuronal development