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Moreover, under hypoxic conditions, the activation of autophagy and mitophagy can reduce ROS production and protect cells from oxidative damage [255]

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In an open-label intervention study in 40 OSMF patients randomized to receive either the conventional treatment (weekly intra-lesional injections of steroids) or daily oral administration of a Curcuma longa Linn extract (600 mg/day) for three months, the burning sensation significantly improved in the curcumin-treated group, while tongue protrusion was reduced with conventional therapy

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