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While App knockin mouse shows no significant neurodegeneration and neuronal loss, it shows synaptic loss and reduction of a part of neuronal cells including active place cells around A plaques 41,60

Hui-Won P, Sun-Hee P, Hyeon-Ju J, Tae-Gyu K, Jeong Hyun L, Seung-Goo K et al

Brain meets body: the blood-brain barrier as an endocrine interface

DAB staining, as indicated by the brown color in the immunohistochemistry analysis, was interpreted as positive expression (Figures 4A,B and see Supplementary Tables S11)