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The American College of Gastroenterology defines chronic DILI as the failure to return to previous bilirubin levels, previous liver enzyme levels, and other signs and symptoms of progressive liver disease (e.g., portal hypertension, hepatic ascites, coagulation abnormalities, and hepatic encephalopathy) within 69 months after the onset of DILI ( 2.2 Potential mechanisms of AILI AILI is one of the leading causes of ALF in many countries, with 9% of patients suffering from APAP-induced ALF with poor prognoses and requiring liver transplantation (Tujios and Lee, 2018)

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Arab JP, Karpen SJ, Dawson PA, Arrese M, Trauner M

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In agreement with this, we observed the highest expression of PrP in cholangiocarcinoma nodes in the liver of Atp7b / mice, whereas PrP depletion almost completely prevented tumor growth

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Public Health 18 , 3797 (2021)

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