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doi: 10.3389/fphar.2021.688625 95 TerzikhanN.VerhammeK

Analysis of endogenous substances and metabolites Endogenous substances in TCM include not only therapeutic constituents but also inherent toxic compounds, such as AC, pyrrolizidine alkaloids (PAs), aristolochic acid, and anthraquinones [54]

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The primary functions of COX-1 are to maintain the integrity of the gastric mucosa and to control gastric blood flow and acid secretion, whereas COX-2 enzyme activated during an inflammatory response upregulates prostaglandin synthesis at the location of ulceration (Mizuno et al