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However, the EAATs include EAAT1 (SLC1A3), EAAT2 (SLC1A2), EAAT3 (SLC1A1), EAAT4 (SLC1A6), and EAAT5 (SLC1A7) can use aspartate and glutamate as substrates ( - dependent, Na + -independent manner ( Figure 1C ) ( 2+ followed by a decrease in cell viability ( In non-neuronal cancer cells, in contrast, the upregulation of the expression of EAATs can promote tumor growth and invasion

The tripeptide glutathione (GSH) is the most abundant low molecular weight thiol in many domains of life ranging from bacteria to eukaryotes (Fahey et al., 1978

To exclude unintended side effects of Cre and Cre inducers or activators with vitamin E deficiency, Gpx4 was deleted prior to vitamin E deprivation

(5) Elute with approximately 5-10 bed volumes of Elution Buffer, collect fractions