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Genetic mutations, such as in the FMR1 gene (fragile X messenger ribonucleoprotein 1), have been linked to genetically induced POF (Ojavee et al., 2023)

Consistent with the idea that this axis is required for resistance to DNA-damaging agents, knockdown of either CrAT or CrOT, which decreased histone acetylation (Extended Data Fig

This increased ATP consumption in astrocytes leads to greater glucose uptake, mediated by an increase in glucose transporter production, which in turn boosts glycolysis and lactate production via LDHA

However, the oncogenic mechanism of HBV integration into the KMT2B locus (HBV- KMT2B integration) in HCC remains unclear