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revealed that endogenous metabolites of vitamin E, particularly -13-COOH, exert anti-inflammatory effects by directly inhibiting 5-lipoxygenase (5-LO), a key enzyme in leukotriene biosynthesis

While we observed subtle fluctuations in canonical ER and lysosomal stress markers, in principle H 2 O 2 does not seem to lead to a robust activation of these pathways in chondrocytes

At the microbial level, taxa such as Lactobacillus and Bifidobacterium favour TRP availability for 5-HT synthesis, whereas enrichment of pro-inflammatory Proteobacteria enhances immune-driven IDO activation and KYN production [175], directly linking microbial ecology to mood-relevant neurochemical pathways