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Both compounds are available through research supply channels

Neuroprotective Signalling : Animal models suggest protective effects on neural tissue, potentially through improved microcirculation, reduced inflammation, and stabilised neurotransmission

Sublingual lozenges dissolve in the mouth and absorb through the buccal mucosa, while intramuscular injections deliver B12 directly into muscle tissuethe gold standard for patients with confirmed deficiency

Why DSIP Was in Category 2 The FDA placed Emideltide (DSIP) in Category 2 of the 503A bulk drug substances list the category reserved for substances that "raise significant safety concerns." While specific details of the FDA's rationale are not always publicly elaborated, Category 2 placement typically reflects concerns about one or more of the following: Limited human safety data in US regulatory standards Concerns about compounding quality control for peptide formulations Potential for misuse or off-label application without adequate medical supervision Insufficient characterization of dose-response relationships The practical effect of Category 2 placement was that compounding pharmacies could not legally prepare DSIP formulations for patients, effectively cutting off access for the patients who relied on it most