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Mitochondrial function: NAD+ supports mitochondrial health and biogenesis while glutathione protects mitochondrial membranes from peroxidation damage, ensuring adequate energy supply for cellular repair processes

However, VEGF blockade alone is often accompanied by compensatory upregulation of Ang-2

Clear cell renal cell carcinoma (ccRCC) ccRCC cells are highly sensitive to the depletion of glutamine and cystine, which are required for GSH synthesis

Additionally, some patients with PCOS undergo ovulation induction treatments such as assisted reproductive technology (ART), leading to an increased incidence of twin or multiple pregnancies, which may further elevate the risk of pregnancy-induced hypertension (Neven et al., 2022