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4 Conclusion Based on the reviewed studies, curcumin is demonstrated to relieve several drugs that induce male reproductive toxicity

This means: No human PK reference data No human bioavailability data No human metabolism or clearance data Rodent-to-human PK extrapolation is therefore speculative This is a major context for research framing

10.1016/j.pbi.2014.04.009 3 FerrettiM.DestroT.TosattoS

Pediatr Res 60 : 299303 Gao XP, Standiford TJ, Rahman A, Newstead M, Holland SM, Dinauer MC, Liu QH, Malik AB 2002 Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox/ and gp91phox/ mice