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The amplitude, polyphasic changes, and the proximal and distal CMAP latencies were recorded, and the nerve conduction velocity was calculated according to previous studies [41, 43]

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In human cells treated with ebselen, intracellular E,Zn-SOD1 was fully oxidized, showing that ebselen efficiently promotes the formation of the SOD1 intramolecular disulphide bond (between Cys57 and Cys146)

While human clinical trials are still needed, the preclinical evidence is compelling