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LT2MYC mice from three separate litters were induced at 8 weeks of age, by taking mice off doxy chow

10.1002/ijc.29642 133 QuailD.JoyceJ

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Reduced GH/IGF-I secretion in the elderly is believed to be responsible for or contribute to many symptoms of aging, including loss of muscle mass, increased adiposity, reduced bone mineral density, and decline in energy levels, along with alterations in psychological indicators of the quality of life[237]