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Tng khng v tng chc nng h min dch

31 LuoD.QuC.LinG.ZhangZ.XieJ.ChenH.et al (2017)

Moreover, studies have shown that Nrf2 can not only combine with an ARE between nucleotide positions 608 to 600 to induce the expression of the Bcl-xL gene, but also bound to ARER3 in thepromoter region of the Bcl-2 gene after Nrf2 is transferred to the nucleus, increasing the Bcl-2 gene transcription, thus realizing the direct regulation of apoptosis by Nrf2 ( Figure 4 ) (58, 59)