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[189] showed that MT-2A was downregulated in alveolar type II cells from the elderly in comparison with young patients

Selected clones can be further evolved and for improved entry by reassembling (optionally in combination with other directed evolution methods described herein) the entire phage genome and subjecting the phage to reiterated cycles of delivery, recovery, amplification, and reassembly (optionally in combination with other directed evolution methods described herein)

Consequently, these findings highlight a new therapeutic challenge: even when direct tumor killing is achieved, ROS-conditioned exosomes may continue to mediate immunosuppression, effectively poisoning the well of the surrounding immune microenvironment

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