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The increase of the expression of MMP2 and MMP7 in the colon indicated that the EpCAM +/ mice are more sensitive to colitis than WT mice, and the elevation of the levels of MMP2, MMP7, MMP8 and MMP12 further confirmed that the DSS administration induced the severer inflammation in the colon of EpCAM +/ mice than the WT mice

The variable weight value (VIP) in Orthogonal Partial Least Squares-Discriminant Analysis is a measure of the expression pattern of each metabolite, the explanatory ability and depth of influence on the categorical discrimination of samples in each group, to explore meaningful differential metabolites, and then use the T-test to verify whether the differential metabolites between groups are significant

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As a thyroid hormone receptor agonist, resmetirom improves hepatic steatosis, inflammation, and fibrosis while providing lipid and cardiovascular benefits