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23 Folate insufficiency also leads to high levels of homocysteinean amino acid produced when proteins break down, and a risk factor for adverse pregnancy outcomes, including NTDs, miscarriage (the most common complication of early pregnancy), preeclampsia, preterm birth, and poor fetal growth

The present invention is further directed to antibody-based therapies which involve administering of anti-polypeptides and anti-polynucleotide antibodies to a mammalian, preferably human, patient for treating, preventing, and/or diagnosing one or more of the described diseases, disorders, and/or conditions

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They should test for B12 levels, mainly in people at risk like the elderly, vegans, and pregnant women