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Encouraged by these positive results, this study has since been extended to a randomized phase 3 trial, with an estimated enrolment of 400 mCRC patients (NCT04516681, see Table 3) [131]

Caution is also advised for patients taking sodium-glucose cotransporter 2 (SGLT2) inhibitors or diuretics, as they may be at higher risk of metabolic complications and electrolyte imbalances

Protection from inactivation of the adenine nucleotide translocator during hypoglycaemia-induced apoptosis by mitochondrial phospholipid hydroperoxide glutathione peroxidase

Semax has immunomodulatory, nootropic and neuroprotective activities