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Yun N, Kang JW, Lee SM (2012) Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties

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Across corticosteroids, acetaminophen, NSAIDs, and opioids, a consistent pattern emerges: Inflammation is suppressed, but tissue repair is impaired Pain signals are blocked, but nervous system sensitivity increases Symptoms are quieted, but root causes remain unaddressed Over time, this creates a widening gap between symptom relief and true recovery

In vitro experiments, it enhanced M2-type macrophage polarization, resulting in elevated cytoprotective effects against antioxidant and inflammatory conditions