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Its main applications are in the treatment of several types of cancer and some autoimmune diseases

A major contributing factor is the low water solubility and limited membrane permeability exhibited by many flavonoids, which result in minimal gastrointestinal absorption (323)

For this reason, patients with a history of immunoglobulin (Ig) Emediated (allergic or anaphylactic) reaction to a sulfonamide antibiotic can receive nonantimicrobial sulfonamides such as celecoxib, chlorthiazide, furosemide and others without elevated risk of an IgE-mediated reaction compared with the general population

Alopecia areata is a disease that occurs when the immune system attacks hair follicles, causing hair loss