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In general, payload release occurs in the TME or after cellular internalization within endosomal/lysosomal compartments, and in some systems may further proceed following endosomal escape, thereby determining the cytosolic availability of the active degrader [184,185,186]

The druglike and orally bioavailable compounds identified herein are active in animal models of schistosomiasis with a broader range of developmental stages targeted than the drug of choice, PZQ

Each earthen-ware pot, measuring 30 cm in depth, and 25 cm in diameter contained 10 kg of soil and five seeds were sown per pot

Wenzel U, Nickel A, Daniel H