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Vortexing creates shear and foam that denature peptides and dissociate the GHK-Cu chelate

For its part, FDA proposed a pilot program where qualified external institutions can collaborate with sponsors to develop and review protocols for first-in-human (FIH) clinical trials intended for investigational new drug (IND) submissions, and several associated draft guidances, including one clarifying when developers can rely on one rigorous, adequate, and well-controlled clinical trial, along with confirmatory evidence, to support drug approvals

This included 166 original reports, 45 review articles, and not a single study tagged as a clinical trial

DOI: 10.1017/S0033583500000123