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Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats

Multiple studies have indicated that CUR displaysantitumorigenic activity in breast cancer (BC) by inducing ferroptosis, with mechanisms that involve promoting SLC1A5-mediated ferroptosis (107) and inducing HO-1 expression (108, 109)

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

It's also studied for gut health, and is commonly used by athletes and in injury-recovery research, though it isn't an approved medication