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ABBV-399 targets the SEMA domain of c-MET, blocking HGF binding and inducing receptor internalization, degradation, or cytotoxic effects [10]

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METHOD DETAILS Drugs and small molecules Simvastatin (Selleckchem, S1792), pitavastatin (Selleckchem S1759), GCN2iB (MedChemExpress, HY-112654), and GSK2606414 PERK inhibitor (Millipore Sigma, 1337531-89-1) were dissolved in DMSO (Thermo Fisher Scientific, BP231), aliquoted, and stored at 80 C

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