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Consistent findings emerged in the cisplatin chemobrain mouse model within the context of chemobrain pathology, demonstrating the protective effects of GENUS on the mouse brain against cisplatin-induced demyelination 57

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Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

There was no evidence of teratogenicity at those doses that were, on a body- weight basis, 15 and 30 times, respectively, the MRHD, and, on the basis of body-surface area, 3.1 and 6.2 times, respectively, the MRHD