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Regarding treatment management, AI-enhanced implantable devices can decrease the rates of heart failure readmission by 35%, while big data-driven personalized treatment regimens can improve patient adherence from 65% to 90% (107, 109)

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Bridging the gap between experimental findings and real-world use remains the central challenge and will depend on well-designed human studies, improved exposure alignment through standardized kratom preparations, and integration of multi-omics approaches capable of capturing interindividual variability in response and risk