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Depending on findings, a doctor may order blood tests (to check for diabetes, B12 deficiency, or infection), nerve conduction studies, MRI of the brain or spine, or a referral to a neurologist

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At present, the most commonly used methods are gene-modified bacteria and surface-modified bacteria, and some natural bacteria such as Lactobacillus (LAB) and Escherichia coli Nissle1917 (EcN) had been proved to be safe clinically (49, 50)